Browsing Pathobiology by Title
Now showing items 1-15 of 15
Altered microRNA Expression Profiles and Regulation of INK4A/CDKN2A Tumor Suppressor Genes in Canine Breast Cancer Models
(2020-01-16)
microRNA (miRNA) expression profiling of cancer versus normal cells may reveal the characteristic regulatory features that can be correlated
to altered gene expression in both human and animal models of cancers. In this ...
Data for: Genome assembly, annotation, and SNP discovery of the blackstripe livebearer Poeciliopsis prolifica shed light on fish placenta evolution
(2023-03-27)
Poeciliidae is a family of live-bearing fish in which some species fully provision eggs before fertilization (lecithotrophy) and some continue to provision embryos after fertilization (matrotrophy). The viviparous matrotrophic ...
From heterosis to outbreeding depression: genotype-by-environment interaction shifts hybrid fitness in opposite directions
(2024-05-19)
In F1 hybrids, phenotypic values are expected to be near the parental means under additive effects or close to one parent under dominance. However, F1 traits can fall outside the parental range, and outbreeding depression ...
Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes)
(2020-07-24)
Animal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more ...
HCAR breast cancer mutations
(2021-11-03)
Sanger sequences of inherited HCAR mutations detected in breast cancer affected individuals.
High-fidelity long-read assembly of the feline gut microbiome
(2024-03-29)
Long-read reference contig assembly of domestic cat rectum/fecal microbiome. DNA was extracted from fecal samples collected from client-owned domestic cats using Qiagen Allprep PowerFecal DNA/RNA kit. PacBio sequencing ...
Host shifting and novel genome features of the microbial pathogen Nosema
(2024-02-14)
Nosema is a diverse fungal genus of unicellular, obligate symbionts of insects and other arthropods. We conducted a comparative genomic analysis of N. muscidifuracis, a Nosema species infecting parasitoid wasp genus ...
Identification of Rickettsia felis DNA in the blood of domestic cats and dogs in the USA
(2021-05-29)
Background: The main vector and reservoir host of Rickettsia felis, an emerging human pathogen causing flea-borne
spotted fever, is the cat flea Ctenocephalides felis. While cats have not been found to be infected with ...
Identification of transcriptome markers in blue catfish cryopreserved sperm to predict male reproductive performance for catfish aquaculture
(2025-05-08)
In hybrid catfish aquaculture, hatch success varies significantly using cryopreserved sperm from different males, but current phenotypic assays only explain a fraction of observed variations. We profiled the sperm transcriptome ...
Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction
(2020-04-08)
X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers ...
Inter-evaluator bias and applicability of feline body condition score from visual assessment
(2024-11-04)
Background: Body Condition Score (BCS) is an effective tool for assessing body weight and overall body composition.
Objectives: To determine whether BCS can be accurately assessed solely from photographs of cats, and to ...
Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs
(2020-05-20)
Activated blood platelets mediate the primary response to vascular injury. Although molecular abnormalities of platelet proteins
occur infrequently, taken collectively, an inherited platelet defect
accounts for a bleeding ...
Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer
(2022-04-13)
16/INK4A/CDKN2A is an important tumor suppressor gene that arrests cell cycle in G1 phase inhibiting binding of CDK4/6 with cyclin D1,leaving the Rb tumor suppressor protein unphosphorylated and E2F bound and inactive. We ...
Videos associated with “Protocol for synchronizing waveforms and videos from electropenetrography studies of arthropods”
(2025-04-08)
Electropenetrography (EPG) is a non-invasive technique for quantifying intra-tissue host-arthropod interactions and behaviors. To use EPG on new species, waveforms must be correlated with behaviors and biological activities. ...