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Browsing Pathobiology by Issue Date

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HCAR breast cancer mutations 

Merner, Nancy; McGuire Sams, Cierla; Shepp, Kasey; Pugh, Jada; Bishop, Madison; https://orcid.org/0000-0002-8954-0155 (2021-11-03)
Sanger sequences of inherited HCAR mutations detected in breast cancer affected individuals.

Identification of Rickettsia felis DNA in the blood of domestic cats and dogs in the USA 

Hoque, Md Monirul; Barua, Subarna; Kelly, Patrick John; Kelly, Chenoweth; Kaltenboeck, Bernhard; Wang, Chengming; 0000-0003-3458-8212 (2021-05-29)
Background: The main vector and reservoir host of Rickettsia felis, an emerging human pathogen causing flea-borne spotted fever, is the cat flea Ctenocephalides felis. While cats have not been found to be infected with ...

Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer 

Agarwal, Payal; Sandey, Maninder; DeInnocentes, Patricia; Bird, R. Curtis (2022-04-13)
16/INK4A/CDKN2A is an important tumor suppressor gene that arrests cell cycle in G1 phase inhibiting binding of CDK4/6 with cyclin D1,leaving the Rb tumor suppressor protein unphosphorylated and E2F bound and inactive. We ...

Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs 

Fang, Juan; Jensen, Eric S.; Boudreauxe, Mary K.; Du, Lily M.; Hawkins, Troy B.; Koukouritaki, Sevasti B.; Cornetta, Kenneth; Wilcox, David A. (2020-05-20)
Activated blood platelets mediate the primary response to vascular injury. Although molecular abnormalities of platelet proteins occur infrequently, taken collectively, an inherited platelet defect accounts for a bleeding ...

Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes) 

Wang, Xu; Pipes, Lenore; Trut, Lyudmila N.; Herbeck, Yury; Vladimirova, Anastasiya V.; Gulevich, Rimma G.; Kharlamova, Anastasiya V.; Johnson, Jennifer L.; Acland, Gregory M.; Kukekova, Anna V.; Clark, Andrew G. (2020-07-24)
Animal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more ...

Altered microRNA Expression Profiles and Regulation of INK4A/CDKN2A Tumor Suppressor Genes in Canine Breast Cancer Models 

Mohammad, Farruk; Kabir, Lutful; Delnnocentes, Patricia; Bird, Richard Curtis (2020-01-16)
microRNA (miRNA) expression profiling of cancer versus normal cells may reveal the characteristic regulatory features that can be correlated to altered gene expression in both human and animal models of cancers. In this ...

Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction 

Rahman, Kh. Shamsur; Chowdhury, Erfan U.; Sachse, Konrad; Kaltenboeck, Bernhard; http://orcid.org/0000-0001-7243-8501 (2020-04-08)
X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers ...

Data for From heterosis to outbreeding depression: genotype-by-environment interaction shifts hybrid fitness in opposite directions 

Wang, Haolong; Su, Baofeng; Zhang, Ying; Shang, Mei; Li, Shangjia; Xing, De; Wang, Jinhai; Bern, Logan; Johnson, Andrew; Al-Armanazi, Jacob; Hasin, Tasnuba; Hettiarachchi, Darshika; Parrales, Abel; Dilawar, Hamza; Bruce, Timothy J.; Dunham, Rex A.; Wang, Xu; 0000-0003-3830-7799 (2023-03-20)

Data for: Genome assembly, annotation, and SNP discovery of the blackstripe livebearer Poeciliopsis prolifica shed light on fish placenta evolution 

Zhang, Ying; Yuridia, Reynoso; Kang, Yuan; Huang, Chen-Che Jeff; Reznick, David; Wang, Xu; 0000-0002-7594-5004 (2023-03-27)
Poeciliidae is a family of live-bearing fish in which some species fully provision eggs before fertilization (lecithotrophy) and some continue to provision embryos after fertilization (matrotrophy). The viviparous matrotrophic ...

Host shifting and novel genome features of the microbial pathogen Nosema 

Xiong, Xiao; Geden, Christopher J.; Zhang, Dapeng; Werren, John H.; Wang, Xu; 0000-0002-7594-5004 (2024-02-14)
Nosema is a diverse fungal genus of unicellular, obligate symbionts of insects and other arthropods. We conducted a comparative genomic analysis of N. muscidifuracis, a Nosema species infecting parasitoid wasp genus ...

High-fidelity long-read assembly of the feline gut microbiome 

Wang, Xu; 0000-0002-7594-5004 (2024-03-29)
Long-read reference contig assembly of domestic cat rectum/fecal microbiome. DNA was extracted from fecal samples collected from client-owned domestic cats using Qiagen Allprep PowerFecal DNA/RNA kit. PacBio sequencing ...

From heterosis to outbreeding depression: genotype-by-environment interaction shifts hybrid fitness in opposite directions 

Wang, Haolong; Su, Baofeng; Zhang, Ying; Shang, Mei; Li, Shangjia; Xing, De; Wang, Jinhai; Bern, Logan; Johnson, Andrew; Al-Armanazi, Jacob; Hasin, Tasnuba; Hettiarachchi, Darshika; Parrales, Abel Paladines; Dilawar, Hamza; Bruce, Timothy J; Dunham, Rex A; Wang, Xu; 0000-0002-7594-5004 (2024-05-19)
In F1 hybrids, phenotypic values are expected to be near the parental means under additive effects or close to one parent under dominance. However, F1 traits can fall outside the parental range, and outbreeding depression ...