College of Veterinary Medicine
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Data for: Genome assembly, annotation, and SNP discovery of the blackstripe livebearer Poeciliopsis prolifica shed light on fish placenta evolution
Poeciliidae is a family of live-bearing fish in which some species fully provision eggs before fertilization (lecithotrophy) and some continue to provision embryos after fertilization (matrotrophy). The viviparous matrotrophic ...
Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer
16/INK4A/CDKN2A is an important tumor suppressor gene that arrests cell cycle in G1 phase inhibiting binding of CDK4/6 with cyclin D1,leaving the Rb tumor suppressor protein unphosphorylated and E2F bound and inactive. We ...
HCAR breast cancer mutations
Sanger sequences of inherited HCAR mutations detected in breast cancer affected individuals.
Identification of Rickettsia felis DNA in the blood of domestic cats and dogs in the USA
Background: The main vector and reservoir host of Rickettsia felis, an emerging human pathogen causing flea-borne spotted fever, is the cat flea Ctenocephalides felis. While cats have not been found to be infected with ...
Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes)
Animal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more ...
Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs
Activated blood platelets mediate the primary response to vascular injury. Although molecular abnormalities of platelet proteins occur infrequently, taken collectively, an inherited platelet defect accounts for a bleeding ...
Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction
X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers ...
Altered microRNA Expression Profiles and Regulation of INK4A/CDKN2A Tumor Suppressor Genes in Canine Breast Cancer Models
microRNA (miRNA) expression profiling of cancer versus normal cells may reveal the characteristic regulatory features that can be correlated to altered gene expression in both human and animal models of cancers. In this ...
Hydrogen sulfide cytoprotective signaling isendothelial nitric oxide synthase-nitricoxide dependent
Previous studies have demonstrated that hydrogen sulfide (H2S) protects against multiple cardiovascular disease states in a similar manner as nitric oxide (NO). H2S therapy also has been shown to augment NO bioavailability ...
Guide for Dissecting the Dog, A
A Guide for Dissecting the Dog has many distinctive features designed to aid students in their study of gross anatomy. In keeping with Dr. Fletcher’s original concept, descriptive material is minimal and most illustrations ...
Osteology of the White-Tailed Deer Odocoileus Virginianus, An
Because of the absence of a comprehensive description of the osseous anatomy of the white-tailed deer, this study was undertaken. The external morphology of each bone is described utilizing the current nomenclature presented ...