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Browsing Pathobiology by Title

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Altered microRNA Expression Profiles and Regulation of INK4A/CDKN2A Tumor Suppressor Genes in Canine Breast Cancer Models 

Mohammad, Farruk; Kabir, Lutful; Delnnocentes, Patricia; Bird, Richard Curtis (2020-01-16)
microRNA (miRNA) expression profiling of cancer versus normal cells may reveal the characteristic regulatory features that can be correlated to altered gene expression in both human and animal models of cancers. In this ...

Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes) 

Wang, Xu; Pipes, Lenore; Trut, Lyudmila N.; Herbeck, Yury; Vladimirova, Anastasiya V.; Gulevich, Rimma G.; Kharlamova, Anastasiya V.; Johnson, Jennifer L.; Acland, Gregory M.; Kukekova, Anna V.; Clark, Andrew G. (2020-07-24)
Animal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more ...

Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction 

Rahman, Kh. Shamsur; Chowdhury, Erfan U.; Sachse, Konrad; Kaltenboeck, Bernhard; http://orcid.org/0000-0001-7243-8501 (2020-04-08)
X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers ...

Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs 

Fang, Juan; Jensen, Eric S.; Boudreauxe, Mary K.; Du, Lily M.; Hawkins, Troy B.; Koukouritaki, Sevasti B.; Cornetta, Kenneth; Wilcox, David A. (2020-05-20)
Activated blood platelets mediate the primary response to vascular injury. Although molecular abnormalities of platelet proteins occur infrequently, taken collectively, an inherited platelet defect accounts for a bleeding ...