Browsing Pathobiology by Title
Now showing items 5-11 of 11
HCAR breast cancer mutations
(2021-11-03)
Sanger sequences of inherited HCAR mutations detected in breast cancer affected individuals.
High-fidelity long-read assembly of the feline gut microbiome
(2024-03-29)
Long-read reference contig assembly of domestic cat rectum/fecal microbiome. DNA was extracted from fecal samples collected from client-owned domestic cats using Qiagen Allprep PowerFecal DNA/RNA kit. PacBio sequencing ...
Host shifting and novel genome features of the microbial pathogen Nosema
(2024-02-14)
Nosema is a diverse fungal genus of unicellular, obligate symbionts of insects and other arthropods. We conducted a comparative genomic analysis of N. muscidifuracis, a Nosema species infecting parasitoid wasp genus ...
Identification of Rickettsia felis DNA in the blood of domestic cats and dogs in the USA
(2021-05-29)
Background: The main vector and reservoir host of Rickettsia felis, an emerging human pathogen causing flea-borne
spotted fever, is the cat flea Ctenocephalides felis. While cats have not been found to be infected with ...
Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction
(2020-04-08)
X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers ...
Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs
(2020-05-20)
Activated blood platelets mediate the primary response to vascular injury. Although molecular abnormalities of platelet proteins
occur infrequently, taken collectively, an inherited platelet defect
accounts for a bleeding ...
Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer
(2022-04-13)
16/INK4A/CDKN2A is an important tumor suppressor gene that arrests cell cycle in G1 phase inhibiting binding of CDK4/6 with cyclin D1,leaving the Rb tumor suppressor protein unphosphorylated and E2F bound and inactive. We ...