Browsing Pathobiology by Title
Now showing items 3-4 of 4
Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction
(2020-04-08)
X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers ...
Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs
(2020-05-20)
Activated blood platelets mediate the primary response to vascular injury. Although molecular abnormalities of platelet proteins
occur infrequently, taken collectively, an inherited platelet defect
accounts for a bleeding ...