Browsing Pathobiology by Title

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Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction

Rahman, Kh. Shamsur; Chowdhury, Erfan U.; Sachse, Konrad; Kaltenboeck, Bernhard; http://orcid.org/0000-0001-7243-8501 (2020-04-08)

X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers ...

Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs

Fang, Juan; Jensen, Eric S.; Boudreauxe, Mary K.; Du, Lily M.; Hawkins, Troy B.; Koukouritaki, Sevasti B.; Cornetta, Kenneth; Wilcox, David A. (2020-05-20)

Activated blood platelets mediate the primary response to vascular injury. Although molecular abnormalities of platelet proteins occur infrequently, taken collectively, an inherited platelet defect accounts for a bleeding ...