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Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 cells


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dc.contributorGeetha Thangiah, thangge@auburn.eduen_US
dc.creatorGeetha, Thangiah
dc.creatorRege, Shraddha D.
dc.creatorMathews, Salome E.
dc.creatorMeakin, Susan O.
dc.creatorWhite, Morris F.
dc.creatorBabu, Jeganathan Ramesh
dc.date.accessioned2020-01-06T21:18:11Z
dc.date.available2020-01-06T21:18:11Z
dc.date.created2013
dc.identifier10.1074/jbc.M112.436279en_US
dc.identifier.urihttp://www.jbc.org/content/early/2013/06/07/jbc.M112.436279.full.pdfen_US
dc.identifier.urihttp://hdl.handle.net/11200/49677
dc.description.abstractTrkA is a cell surface transmembrane receptor tyrosine kinase for nerve growth factor (NGF). TrkA has an NPXY motif and kinase regulatory loop similar to insulin receptor (INSR) suggesting that NGF→TrkA signaling might overlap with insulin→INSR signaling. During insulin or NGF stimulation TrkA, insulin receptor substrate-1 (IRS-1), INSR (and presumably other proteins) forms a complex in PC12 cells. In PC12 cells, tyrosine phosphorylation of INSR and IRS-1 is dependent upon the functional TrkA kinase domain. Moreover, expression of TrkA kinase−inactive mutant blocked the activation of Akt and Erk5 in response to insulin or NGF. Based on these data, we propose that TrkA participates in insulin signaling pathway in PC12 cells.en_US
dc.formatPDFen_US
dc.relation.ispartofJournal of Biological Chemistryen_US
dc.relation.ispartofseries0021-9258en_US
dc.subjectTrkA, insulin receptor, IRS-1, NGF, insulinen_US
dc.titleNerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 cellsen_US
dc.typeTexten_US
dc.type.genreJournal Article, Academic Journalen_US
dc.citation.volume288en_US
dc.citation.issue33en_US
dc.citation.spage23807en_US
dc.citation.epage23813en_US
dc.description.statusPublisheden_US
dc.description.peerreviewYesen_US

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