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Browsing Harrison School of Pharmacy by Issue Date

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Purinergic P2Y2 Receptor Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells NEW AP-1 TRANSCRIPTION FACTOR SITE AND NEGATIVE REGULATOR 

Liu, Yiwei; Zhang, Lingxin; Wang, Chuan; Roy, Shama; Shen, Jianzhong; http://orcid.org/0000-0002-9979-6269 (2020-04-08)
We recently reported that the P2Y2 receptor (P2Y2R) is the predominant nucleotide receptor expressed in human coronary artery endothelial cells (HCAEC) and that P2Y2R activation by ATP or UTP induces dramatic up-regulation ...

Induction of C-X-C Chemokine Receptor Type 7 (CXCR7) Switches Stromal Cell-derived Factor-1 (SDF-1) Signaling and Phagocytic Activity in Macrophages Linked to Atherosclerosis* 

Ma, Wanshu; Liu, Yiwei; Ellison, Nicholas; Shen, Jianzhong (2020-01-02)
The discovery of CXCR7 as a new receptor for SDF-1 places many previously described SDF-1 functions attributed to CXCR4 in question, though whether CXCR7 acts as a signaling or “decoy” receptor has been in debate. It ...

Active Site-labeled Prothrombin Inhibits Prothrombinase in Vitro and Thrombosis in Vivo 

Kroh, Heather K.; Panizzi, Peter; Tchaikovski, Svetlana; Baird, T. Regan; Wei, Nancy; Krishnaswam, Sriram; Tans, Guido; Rosing, Jan; Furie, Bruce; Furie, Barbara C.; Bock, Paul E. (2020-09-16)
Mouse and human prothrombin (ProT) active site specifically labeled with D-Phe-Pro-Arg-CH2Cl (FPR-ProT) inhibited tissue factor-initiated thrombin generation in platelet-rich and platelet-poor mouse and human plasmas. ...

The P2Y(2) Nucleotide Receptor Mediates Tissue Factor Expression in Human Coronary Artery Endothelial Cells 

Ding, Ling; Ma, Wanshu; Littmann, Timothy; Camp, Riley; Shen, Jianzhong (2020-09-16)
The discovery of the role of P2Y12 receptor in platelet aggregation leads to a new anti-thrombotic drug Plavix; however, little is known about non-platelet P2Y receptors in thrombosis. This study tested the hypothesis ...