An Fe(II) Complex Detects Hydrogen Peroxide with 1H and 19F Magnetic Resonance Imaging Responses

Abstract

We report the fluorinated quinol-containing ligand, 1,8-bis(2,5-dihydroxy-4-fluorobenzyl)-1,4,8,11-tetraazacyclotetradecane (F2H4qp4), and its highly water- and air-stable Fe(II) complex. Upon oxidation by H2O2, the 19F MRI signal of the complex decays while its 1H MRI contrast increases; these spectroscopic responses enable the complex to ratiometrically detect H2O2.