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dc.creatorWang, Zonghua
dc.creatorZhou, Chengfeng
dc.creatorXia, Jianfei
dc.creatorVia, Brian
dc.creatorXia, Yanzhi
dc.creatorZhang, Feifei
dc.creatorLi, Yanhui
dc.creatorXia, Linhua
dc.date.accessioned2013-04-04T22:20:56Z
dc.date.available2013-04-04T22:20:56Z
dc.date.created2013
dc.date.issued2013-04-04
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0927776513000544en_US
dc.identifier.urihttp://hdl.handle.net/11200/44162
dc.description.abstractA novel triple functionalized drug delivery system was synthesized by encapsulation of superparamagnetic graphene oxide (GO) and doxorubicin (DOX) with folic acid (FA) conjugated chitosan (CHI). The carrier exhibited a high loading efficiency (0.98 mg/mg), a high saturation magnetization (10.5 emu/g) and a prolonged release rate. A real-time monitoring method on the drug release from graphene oxide (GO) was reported using DOX as the model drug. The release mechanism of DOX at different pH was investigated via monitoring the time dependency of the accumulative drug release. Results show that the drug release of DOX was pH sensitive as observed at pH 5.3 and pH 7.4 PBS solutions, the lower pH values lead to weaker hydrogen bonds and degradation of CHI, and thus result in a higher release rate of DOX. Especially, this system could be applied as a dual-targeted drug nanocarrier by combined biological (active) and magnetical (passive) targeting capabilities. Our research suggests that a novel triple functionalized, pH-responsive nanocarrier for anticancer drug has been synthesized.en_US
dc.publisherElsevieren_US
dc.relation.ispartofColloids and Surfaces B: Biointerfacesen_US
dc.subjectcancer, drug, nanoparticle, functionalized, nanocarrier, inorganic,en_US
dc.titleFabrication and characterization of a triple functionalization of graphene oxide with Fe3O4, folic acid and doxorubicin as dual-targeted drug nanocarrieren_US
dc.typeCollectionen_US
dc.type.genreJournal Articleen_US
dc.citation.volume106en_US
dc.citation.issue1en_US
dc.citation.spage60en_US
dc.citation.epage65en_US
dc.description.peerreviewYesen_US


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